Klotho 抗体
Quick Overview for Klotho 抗体 (ABIN360924)
抗原
See all Klotho (KL) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody detects Mouse Klotho. Other species not tested.
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纯化方法
- Protein A/G Affinity Chromatography
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过滤
- 0.2 μm filtered
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免疫原
- Purified Mouse Recombinant protein of Klotho
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亚型
- IgG2
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anti-Klotho (KL) (AA 516-955) antibody
KL 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 401-500) antibodyKL 适用: 小鼠, 人, 大鼠 IHC (p), IHC (fro), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 517-956) antibodyKL 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 720-769) antibodyKL 适用: 人, 大鼠, 兔, Cow, 犬, Pig, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 251-300) antibodyKL 适用: 小鼠, 人, 大鼠, 兔, 马, 犬, 豚鼠, Bat, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (Middle Region) antibodyKL 适用: 小鼠, 人, 大鼠, 兔, 马, Cow, 犬, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (N-Term) antibodyKL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (Middle Region) antibodyKL 适用: 小鼠, 人, 大鼠, 兔, 马, Cow, 犬, 豚鼠, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (Center) antibodyKL 适用: 小鼠, 人, 大鼠 WB, IHC (p), EIA, IF 宿主: 兔 Polyclonal unconjugated
anti-Klotho (KL) (AA 765-981) antibodyKL 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1/500 - 1/1000. Immunohistochemistry on frozen sections: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.
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缓冲液
- 0.2 μm filtered solution in PBS, None
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Klotho (KL)
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别名
- Klotho
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背景
- Animal models of human aging which display the characteristic diseases associated with aging provide insight into the cause of such diseases. Recently a transgenic mouse model, called Klotho, with several premature aging phenotypes has been described. They display premature aging phenotypes such as Osteoporosis, age related skin changes, ectopic calcifications, atrophy of genital organs and thymus, emphysema and short life span. Klotho (Kl) protein associated with the Klotho mutation is a 1014 amino acid long peptide. It has a putative signal sequence at its N-terminus and a single transmembrane domain near its C-terminus, which is postulated to anchor it to the membrane. kl gene expression was observed to be tissue specific. Improvement of systemic aging phenotypes in kl/kl mice occurs even when the exogenous expression was limited to some organs, suggesting that KL associated aging is regulated through a humoral signaling pathway. KL has been reported to be localized on the cell surface when expressed on Cho cells. Human kl cDNA is expected to encode a protein of 1012 amino acids.Synonyms: EC 3.2.1.31, KL, Klotho
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基因ID
- 16591
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NCBI登录号
- NP_038851
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UniProt
- O35082
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途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hormone Activity, Growth Factor Binding
抗原
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